Commercial aviation remains one of the industries most disrupted by COVID-19 and has endured one of the industry’s worst financial years on record. While travelers continue to stay at home as COVID-19 has begun to resurge in many places, new COVID-19 vaccine distribution efforts present commercial airlines with a financial and humanitarian opportunity. Cargo bottlenecks, capacity shortages, and limited cold-chain infrastructure will challenge air cargo distribution efforts, and commercial airlines have a real chance to capitalize on new cargo transport needs to get planes back in the skies and help get travelers back on the go.